Statins and Chronic Fatigue

Chronic fatigue is the most common complaint of people seeking treatment from primary care physicians. This condition is the chief complaint in nearly one quarter of all patients they see. Chronic fatigue is defined as intractable fatigue lasting more than 6 months and not reversed by sleep.

A major contributor to this condition is ubiquinone deficiency secondary to the use of statin drugs. During this year alone some 60 million people in the United States will be taking these drugs.

The collateral damage to ubiquinone synthesis from statin drug disruption of our vital mevalonate pathway has been known from the time these drugs were first released.

Energy is required by all every cell in our body and in the absense of adequate stores of ubiquinone, energy production can not occur or occurs only slowly. Inhibition of ubiquinone biosynthesis by the use of statin drugs is well documented.

The effectiveness of ubiquinone supplementation on heart failure patients has long been stressed by cardiolgist Peter Langsjoen in his excellent series of papers on this subject. The relationship of heart failure to chronic fatigue is obvious - both may be caused by ubiqinone deficiency secondary to statin drug use.

Duane Graveline MD MPH
Former USAF Flight Surgeon
Former NASA Astronaut
Retired Family Doctor


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